Publications

Roche KC, Gracz AD, Liu XF, Newton V, Akiyama H, Magness ST. - SOX9 Maintains Reserve Stem Cells and Preserves Radio-resistance in Mouse Small Intestine. Gastroenterology. Epub 2015 Jul 10.

Van Landeghem L, Santoro MA, Mah AT, Krebs AE, Dehmer JJ, McNaughton KK, Helmrath MA, Magness ST, Lund PK. - IGF1 stimulates crypt expansion via differential activation of 2 intestinal stem cell populations. FASEB J. 2015 Jul;29(7):2828-42. Epub 2015 Apr 2.

Gracz AD, Williamson IA, Roche KC, Johnston MJ, Wang F, Wang Y, Attayek PJ, Balowski J, Liu XF, Laurenza RJ, Gaynor LT, Sims CE, Galenko JA, Li L, Allbritton NL, Magness ST. - A high-throughput platform for stem cell niche co-culturs and downstream gene expression analysis. Nature Cell Biology, 2015 Mar;17(3):340-9. Epub 2015 Feb 9

Rahmani W, Abbasi S, Hagner A, Raharjo E, Kumar R, Hotta A, Magness S, Metzger D, Biernaskie J. - Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type . Developmental Cell, 2014 Nov 26. pii: S1534-5807(14)00688-1

Gracz AD, Magness ST. - Defining hierarchies of stemness in the intestine: biomarkers and regulatory pathways. Am J Physiol Gastrointest Liver Physiol. 2014 Aug 1;307(3):G260-73. Epub 2014 Jun 12. Review.

Mah AT, Van Landeghem L, Gavin HE, Magness ST, Lund PK. - Impact of diet-induced obesity on intestinal stem cells: hyperproliferation but impaired intrinsic function that requires insulin/IGF1. Endocrinology, 2014, in press.

Ahmad AA, Wang Y, Gracz AD, Sims CE, Magness ST, Allbritton NL. - Optimization of 3-D organotypic primary colonic cultures for organ-on-chip applications. J Biol Eng. 2014 Apr 1;8(1):9.

Wang Y, Ahmad AA, Sims CE, Magness ST, Allbritton NL. - In vitro generation of colonic epithelium from primary cells guided by microstructures. Lab Chip. 2014 May 7;14(9):1622-31.

Wang Y, Ahmad AA, Shah PK, Sims CE, Magness ST, Allbritton NL. - Capture and 3D culture of colonic crypts and colonoids in a microarray platform. Lab Chip. 2013 Oct 29;13(23):4625-34.

Magness ST, Puthoff BJ, Crissey MA, Dunn J, Henning SJ, Houchen C, Kaddis JS, Kuo CJ, Li L, Lynch J, Martin MG, May R, Niland JC, Olack B, Qian D, Stelzner M, Swain JR, Wang F, Wang J, Wang X, Yan K, Yu J, Wong MH. - A multicenter study to standardize reporting and analyses of fluorescence-activated cell-sorted murine intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2013 Oct;305(8):G542-51

Gonzalez LM, Williamson IA, Piedrahita JA, Blikslager AT, Magness ST - Cell lineage identification and stem cell culture in a porcine model for the study of intestial epithelial regeneration. PLoS One. 2013 Jun 28;8(6)

Wang F, Scoville D, He XC, Mahe M, Box A, Perry J, Smith NR, Nanye NL, Davies PS, Fuller MK, Haug JS, McClain M, Gracz AD, Ding S, Stelzner M, Dunn JCY, Magness ST, Wong MH, Martin M, Helmrath M, and Li L - Isolation and Characterization of Intestinal Stem Cells Based on Surface Marker Combinations and Colony-Formation Assay.

Gastroenterology 2013 May 2.

Gracz AD*, Fuller MK*, Wang F, Li L, Stelzner M, Dunn JCY, Martin M, Magness ST - CD24 and CD44 mark human intestinal epithelial cell populations with characteristics of active and facultative stem cells.

Stem Cells 2013 Apr 4 - *Authors contributed equally to this work

Barry ER, Morikawa T, Butler BL, Shrestha K, de la Rosa R, Yan KS, Fuchs CS, Magness ST, Smits R, Ogino S, Kuo CJ, Camargo FD. - Restriction of intestinal stem cell expansion and the regenerative response by YAP.

Nature. 2013 Jan 3;493(7430):106-10. doi: 10.1038/nature11693. Epub 2012 Nov 25.

Ding S., Walton, K.L.W., Blue, R.E., MacNaughton, K., Magness, S.T., Lund P.K. - Mucosal healing and fibrosis after acute or chronic inflammation in wild type FVB-N mice and C57BL6 procollagen 1(I)-promoter-GFP reporter mice. PLoS One. 2012;7(8):e42568. doi: 10.1371/journal.pone.0042568. Epub 2012 Aug 3.

Gracz AD, Puthoff BJ, Magness ST. - Identification, isolation, and culture of intestinal epithelial stem cells from murine intestine. Methods Mol Biol. 2012;879:89-107. (Book Chapter)

Stelzner M, Helmrath MA, Dunn JC, Henning SJ, Houchen CW, Kuo CJ, Lynch JP, Li L, Magness ST, Martin MG, Wong MH, Yu J. - A nomenclature for intesintal in vitro cultures. Am J Physiol Gastrointest Liver Physiol. 2012 Apr 5.

Van Landeghem, L.M., Santoro, A., Krebs, A., Mah, A.T., Dehmer, J.J., Gracz., A.D., Scull, B.P., McNaughton, K., Magness, S.T., and Lund, P.K., - Activation of two distinct Sox9-EGFP expressing intestinal stem cell populations during crypt regeneration after irradiation.Am J Physiol Gastrointest Liver Physiol. 2012 May;302(10):G1111-32. Epub 2012 Feb 23.

Fox, R.G., Magness, S.T., Kujoth, G.C., Prolla, T.A., Maeda, N. - Mitochondrail DNA polymerase editing mutation, POLGD257A, disturbes stem-progenitor cell cycling in the small intestine and restricts excess fat absorption. Am J Physiol Gastrointest Liver Physiol. 2012 May 1;302(9):G914-24. Epub 2012 Feb 16.

VanDussen, K.L., Carulli, A.J., Keeley, T.M., Patel, S.R., Puthoff, B.J., Magness, S.T., Tran, I.T., Maillard, I., Siebel, C.W., Kolterud, A., Grosse, A.S., Gumucio, D.L., Ernst, S.A., Tsai, Y-H, Dempsey, P.J., and Samuelson, L.C. - Notch Signaling Modulates Proliferation and Differentiation of Intestinal Crypt Base Columnar Stem Cells; Development. 2012 Feb;139(3):488-97. Epub 2011 Dec 21.

Ramalingam, H., Daughtridge, G.W., Johnston, M.J., Gracz, A.D. Magness, S.T. - Distinct levels of Sox9 expression mark colon epithelial stem cells that form colonoids in culture. American Journal of Physiology Gastro, 2012 Jan;302(1):G10-20. Epub 2011 Oct 13.

Gracz, A.D., Magness S.T.; Sry-box (SOX) transcription factors in gastrointestinal physiology and disease. Am J Physiol Gastrointest Liver Physiol. 2011 Apr;300(4):G503-15. Epub 2011 Feb 3. Review.

von Furstenberg R.J., Gulati A.S., Baxi A., Doherty J.M., Stappenbeck T.S., Gracz A.D., Magness S.T., Henning S.J., -Sorting mouse jejunal epithelial cells with CD24 yeilds a population with characteristics of intestinal epithelial stem cells. Am J Physiol Gastrointest Liver Physiol. 2010 Dec 23.

Ding S, Chi MM, Scull BP, Rigby R, Schwerbrock NM, Magness S, Jobin C, Lund PK. - High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. PLoS One. 2010 Aug 16;5(8). pii: e12191.

Gracz, A.D., Ramalingam, S., Magness S.T. – Sox9-expression marks a subset of CD24- expressing small intestine epithelial stem cells that form organoids in vitro. Am J Physiol Gastrointest Liver Physiol. Epub 2010 Feb 25

Formeister E.J., Sionas A.L., Lorance D.K., Barkley C.L., Lee G.H., Magness S.T. - Distinct SOX9 Levels Differentially Mark Stem/Progenitor Populations and Enteroendocrine Cells of the Small Intestine Epithelium. Am J Physiol Gastrointest Liver Physiol. 2009, May; 296(5):G1108- 18. Epub 2009 Feb 19

Ramocki, N.M, Wilkins, H.R., Magness S.T., Simmons, J.G., Scull, B.P., McNaughton, K.K., Lund, P.K. – Insulin receptor substrate-1 deficiency promotes apoptosis in the putative intestinal crypt stem cell region, limits Apcmin/+ tumors, and regulates Sox9. Endocrinology, 2008, 149(1):261-7.

Karrasch, T., Kim, J-S., Muhlbaur, M., Magness, S.T., Jobin, C. - Gnotobiotic IL-10-/-;NF- kBEGFP mice reveal the critical role of TLR/NF-kB signaling in commensal bacteria-induced colitis. Journal of Immunology, 2007, 178(10), 6522-32

Taranova O.* and Magness S.T.*, Fagan B.M., Wu Yongqin, Hutton S.R., Pevny L.H. – SOX2 is a dose-dependent regulator of retinal neural progenitor competence. Genes and Development, 1;20(9):1187-202, 2006 *Authors contributed equally

Yang L., Magness S.T., Bataller R., Rippe R.A., Brenner D.A. – NF-kB activation in Kupffer cells after partial hepatectomy. Am J Physiol Gastrointest Liver Physiol., 2005, 289(3):G530-8

Pam Ellis, B. Mathew Fagan, Scott T. Magness, Scott Hutton, Olena Taranova, Shigemi Hayashi, Andrew McMahon, Mahendra Rao and Larysa Pevny - SOX2, a persistent marker for multipotential neural stem cells derived from ES cells, the embryo or the adult. Developmental Neuroscience, 2004, vol. 26,148-165.

Magness S.T., Bataller R., Yang L., Brenner D.A – A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Hepatology, 2004, vol. 40(5), 1151-9.

Magness S.T., Jijon, H., Van Houten Fisher, N., Sharpless, N.E., Brenner D.A., Jobin C. – In vivo pattern of LPS and anti-CD3-induced NF-kB activation using a novel gene targeted EGFP reporter gene mouse. Journal of Immunology, 2004, vol. 173, no. 3.

Magness S.T., Maeda N., Brenner D.A. – An Exon 10 Deletion in the Mouse Ferrochelatase Gene has a Dominant Negative Effect and Causes Mild Protoporphyria. Blood, 2002, vol. 100, no.4, 1470-1477

Magness S.T., Tugores A. and Brenner D.A. - Analysis of Ferrochelatase Gene Expression during Hematopoietic Development of Embryonic Stem Cells. Blood, 2000, vol. 95, no.11, 3568- 3577

Magness S.T. and Brenner D.A. - Disruption of the Mouse Ferrochelatase Gene Producing an Exon 10 Deletion. Biochimica et Biophysica Acta, 1999, vol. 1453, 161-174

Bloomer J., Bruzzone C., Zhu L., Scarlett Y., Magness S., Brenner D. - Molecular Defects in Ferrochelatase in Patients with Protoporphyria Requiring Liver Transplantation. Journal of Clinical Investigation, 1998, vol. 102, no. 1, 107-114

Magness S.T., Tugores A., Diala E.S., Brenner D.A. - Analysis of Human Ferrochelatase Promoter in Transgenic Mice. Blood, 1998, vol. 92, no. 1, 320-328

Magness S.T. and Brenner D.A. - Recombinant Adenovirus Expressing Ferrochelatase Corrects Biochemical Defect in Protoporphyric Cells. Human Gene Therapy, 1995, Vol. 6, No. 10, 1285-90

Tugores A., Magness S.T., Brenner D.A. - A Single Promoter Directs Both Housekeeping and Erythroid Preferential Expression of the Human Ferrochelatase Gene. Journal of Biological Chemistry, 1994, Vol. 269, No. 49, 30789-30797

Magness S.T., Tugores A., Christensen S.R., Wagner-McPherson C., Evans G.A., Naylor E.W., Brenner D.A. - Ferrochelatase Gene in a Patient with Protoporphyria. Human Molecular Genetics, 1994, Vol. 3, No.9 1695-16972.