2015 Gastroenterology: Sox9 & rISCs

2015 FASEB J: IGF1 Activation of ISCs

2015 Nature CB: Stem Cell Niche

2014 Dev Cell: Mesenchymal Stem Cell

2014 AJP-GI: ISC Hierarcy Review

2014 Endocrinology: Obesity ISCs

2014 J Biol Eng: 3D Colon Culture

2014 Lab on Chip: Ex vivo Colon

2013 Lab on Chip: Crypt Culture

2013 AJP-GI: Multi-Center FACS

2013 PLoS One: Porcine ISC Culture

2013 Gastroenterology: ISC Culture

2013 Stem Cells: Human ISC Iso/Cult

2013 Nature: YAP

2012 PLoS One: Fibrosis

2012 Methods Mol Biol: ISC Culture

2012 AJP-GI: ISC Nomenclature

2012 AJP-GI: ISC Irradiation

2012 AJP-GI: POLG2257A mutant ISC

2012 Development: Notch ISCs

2011 AJP-GI: Sox9 Colon/Colonoids

2011 AJP-GI: Sox Review

2011 AJP-GI: CD24 ISC Marker

2010 PLoS One: Inflammation

2010 AJP-GI: CD24 ISC Enteroids

2010 AJP-GI: Sox9 ISC Marker

2008 Endocrinology: IGF Colon Tumor


The dermal papilla (DP) provide instructive signals required to activate epithelial progenitors and initiate hair follicle regeneration. DP cell numbers fluctuate over the hair cycle, and hair loss is associated with gradual depletion/atrophy of DP cells. How DP cell numbers are maintained in healthy follicles remains unclear. We performed in vivo fate mapping of adult hair follicle dermal sheath (DS) cells to determine their lineage relationship with DP and found that a subset of DS cells are retained following each hair cycle, exhibit self-renewal, and repopulate the DS and the DP with new cells. Ablating these hair follicle dermal stem cells and their progeny retarded hair regrowth and altered hair type specification, suggesting that they function to modulate normal DP function. This work identifies a bipotent stem cell within the adult hair follicle mesenchyme and has important implications toward restoration of hair growth after injury, disease, and aging.

Rahmani w, Abbasi S, Hagner A, Raharjo E, Kumar R, Hotta A, Magness S, Metzger D, Biernaskie J.

Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type

Developmental Cell, 2014 Nov 26. pii: S1534-5807(14)00688-1